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Questions and answers imported from the source spreadsheet.
Question: Celiac Disease - What genetic markers are checked?
Answer:
On Celiac Disease part of the test we look 6 different genetic markers from genes - HLA DQA1; HLA-DRA; HLA-DQB1; HLA-DQB7; HLA-DQ8 and DQ2.
Question: What Genes are tested for Breast Cancer
Answer:
Thank you for asking, for breast cancer we analyse TP53, RAD51B, ATM, TNRC9, BRCA1, and BRCA2 genes.
Mainly one marker from a gene, apart ATM (8 markers) and BRCA1 (2 markers).
Breast cancer TP53; 1 marker
Breast cancer RAD51B; 1 marker
Breast cancer ATM; 8 markers
Breast cancer TNRC9; 1 marker
Breast cancer BRCA1; 2 markers
Breast cancer BRCA2 ; 1 marker
2017-05-02 00:00:00
Question: What is tested
Answer:
Lupus is not a typical genetic disorder. It is an autoimmune disorder.Our GeneWell tests analysis SNPs linked to systemic lupus erythematosus. The selected variants are from genes
STAT4, IRF5, ITGAM, TNF-a, HLA-DQA1, SKIV2L, STAT4, ITGAM
For this purpose the best way for proceeding is the GeneWell test.
For lupus related mutations I would suggest DNASE1 (two potential mutations) and DNASE1L3 (one potential mutation) genes. The partner price for analyzing the 3 mentioned positions is 240 euros. <-- We charge 480€
Question: Can we test for this
Answer:
It is done VIA GTL AU - https://www.gtldna.com.au/inherited-diseases/ - AU$1200
2017-08-28 00:00:00
Question: Can we test for this
Answer:
In depth testing on the MTHFR Gene is not done as a separate test, It is however included in the Genetic Predisposition test with in the tests remit.
Question: Do you do testing for the cancer gene MEN1
Answer:
No, the MEN1 is not included to our GeneWell panel - Will be included in the cancer pannel when on sale
Question: how many genes tested
Answer:
92 genes most commonly associated to cancers - Inc MEN1
Question: What genes are used for baldness
Answer:
two SNPs (rs6625163 and rs6113491). For rs6625163 the risk allele is A and for rs6113491 the risk allele is C. The final individual genetic risk percentage is calculated based on the both SNPs allele odd ratios and allele frequences.
Question: genotype as TT and in the summary the same genotype is in a form of AA
Answer:
Since A and T are complementary base pairs (A is always linked to T and G is always linked to C) the content of the results would remain the same
Question: Which specific genes do you test for with regards to colorectal cancer
Answer:
MLH1, MSH2, MSH6 genes for Lynch syndrome which is also called hereditary non-polyposis colon cancer
Question: Good source of information
Answer:
https://www.asperbio.com/asper-oncogenetics/
Question: How many SNIPS are tested
Answer:
Testing with DDC uses 28 SNIPS
Question: Can you provide electropherograms?
Answer:
Asper confirmed NO
Question: How long are samples good for?
Answer:
The stabilizing solution should keep the sample in good condition for a month. Please advise the client keep the sample in refrigerator (+2 ... +8 C) and not to freeze it!
Question: Can we do the Gutwell test on a child?
Answer:
We would not recommend testing children under 3 years old because microbiomes continue to develop until 3 years of age. So, for a one year old the GutWell test is not informative enough. If the child has continuous constipation please ask the family to consult with a doctor and/or nutrition specialist.
Question: I wanted to ask what is the maximum number of polymorphisms that you can detect with your lactose intolerance test
Answer:
We perform single-nucleotide polymorphism -13910C>T (HGVS: g.30366C>T, rs4988235) analysis of the LCT gene that has been associated with adult-type lactose intolerance in Caucasian populations. Individuals who are homozygous for C allele are likely to be lactose intolerant (Enattah et al., 2002).
Question: If a client is currently taking probiotics. Would it be best to come off them for some times before collecting the sample?
Answer:
If your client intends to see his/her current gut condition without the help of probiotics please advise your client to stop probiotics use for one month and then send us the sample. In case your client needs to test how probiotics use may change the microbiome then she/he could order a combo test (initial test and follow-up test) before and after probiotics use .
Question: Can i get my 9 months old daughter tested for her gut microbiome ? She is currently on Klaire labs infant probiotic , would that influence the results?
Answer:
Yes, basically a 9-month old child can be tested to reflect her current microbiome status. In case the mother is breastfeeding her daughter, then the results will reflect mother´s dietetic habits. Please note that a 9-month old´s microbiome is just in a developing stage and may not have all the bacteria species that adults have. Microbiomes are almost fully developed by the age of 3 years, after that the microbiome would not change too much anymore. Regarding the probiotics use - test should be done at least 2 weeks after probiotics use. Then the probiotics effect is over and usual microbiome status is present.
Question: Antibiotics and other medications
Answer:
According to the studies antibiotics have been shown to diminish overall variety of gut bacteria. We have not had enough cases of patients who send their microbiome samples before and after antibiotics course that we could statistically conclude something from these results. As there are really numerous scientific publications which say that antibiotics affect the variety of gut bacteria, then most likely we should trust this. Probably many medicines, including antidepressants and drugs for Parkinson disease have some impact to microbiome as well. So far we have not analyzed any sample from person with Parkinson disease, at least patients have not stated on submission form that they have this condition. We ask on our submission form about the medicines you take only because of our own statistics purposes, we exclude these persons from the reference group. We would not interpret the results differently depending of the medicines usage, meaning we can not give you any conclusions on the report connected with medicines. In case there is a significant lack of certain bacteria, we will report this.
Question: DELAYED SAMPLES REACHING LAB
Answer:
We have analyzed the GutWell samples that have been on the way for one and half month in case the sample is taken according to instructions and the tube is not overfilled. The lab will tell about the condition after it arrives. The ideal is if the sample is on the way up to one month.
Question: Minimum Age for Celiac testing
Answer:
We confirm that celiac disease can be tested in children of 1 and 3 years.
Question: Can we test for Lynch Syndrome?
Answer:
Yes, or lab is testing for Lynch syndrome: NGS sequencing with CNV analysis of MLH1, MSH2 and MSH6 genes costs 1035 eur. Each gene separately costs 464 eur in case doctor recommended testing just one certain gene. We can also offer MLPA analysis (deletions/duplications): MLH1, MSH2 genes together cost 310 eur and MSH6 gene 310 eur. - ASK MANAGEMENT FOR COSTS
Question: How many swabs are needed to test all 3 tests at once?
Answer:
2 swabs (1 kit) is enough for all 3 tests.
Question: Can children under 3 be tested
Answer:
3 Years? Yes it can but keep in mind that when they are young they would still be developing so their intolerances might change and vary more frequently than adults
Question: There is a genetic disease called Tay–Sachs that can cause death in children.
Answer:
Lab reply: Yes, we do offer testing for Tay–Sachs disease but we´d require a EDTA blood sample (2-4 ml venous blood).
We can sequence whole coding area of HEXA gene, price is 812 eur.
In case genetic testing is previously done and mutation found, then we can offer familial mutation confirmation, price is 110 EUR for one mutation.
Question: Is it possible to check with a swab sample whether a person carries this gene?
Answer:
Kevin reply for the price: We can offer as follows:
We also need to make sure we recover any cost of kit and transport to send over if it’s a one-off order.
Question: If a client is currently following a specific diet, does this have any impact on the test results, or do they need to stop or change their diet prior to testing to ensure accurate results?
Answer:
we investigate genetic markers, which do not depend on diet or metabolic aspects. It is precisely on the basis of the genetic results that a personalised diet should then be suggested based on the test results.